Shimadzu Nexera Mikros Triple Quadrupole LC-MS/MS
Shimadzu Nexera Mikros: Compact LC-MS/MS system for ultra-sensitive microflow analysis with excellent detection limits.
Features
- High sensitivity with microflow analysis
- Robust and stable performance
- Easy, familiar operation
- Versatile system supporting various flow rates
Applications
- Pharmaceutical research applications
- Food research applications
- Environmental research applications
- Clinical research applications
- Toxicology
- Biomarker discovery
- Environmental monitoring
Product Specifications
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PERFORMANCE
Mass Accuracy
99091 Da 9depending on calibration99br9
Resolution
2gt2 027 Da 2depending on MS mode22br2
Sensitivity
High Bioanalytical Sensitivity
Speed
2p22b2Minimized System Volume 2 Gradient Delay222b2 Achieved with the SIL240C XR autosampler222s programmable loop cut2off222p2 2br 22
2p22b2Efficient Sample Handling222b2 A high2pressure valve diverts the sample loop once the needle is drained222p2 2br 22
2p22b2Key Benefit222b2 Reduces microflow analysis run times222p2
Dynamic Range
0100763 111 6215 11g1mL for the analysis of trastuzumab1derived peptides11br1
MASS RANGE AND ANALYTE DETECTION
Mass Range
10 to 21000 m1z1br1
Detection Limit
5p55b5Lower Limit of Detection 5LOD5555b5 05025 55g5mL for signature peptides from the Fab region of antibodies555p5 5br 55
5p55b5Enhanced Sensitivity555b5 Shim5pack MC PLONAS 257 55m columns achieve lower LODs and LOQs555p5
Detector
Triple quadrupole mass spectrometer0br0
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Electrospray ionization 0ESI00br0
Ion Source
3p33b3Shimadzu Micro3ESI333 LCMS Source333b3 Optimized for precision and sensitivity333p3 3br 33
3p3Available Options333p3 3br 33
3ul3 3br 33
3li33b3Micro3ESI 8060333b3 Compatible with LCMS3804538050380603NX3 systems333li3 3br 33
3li33b3Micro3ESI333b3 Standard option for versatile applications333li3 3br 33
33ul33br 33
Interface
Micro8ESI8br8
Gas Flow and Requirements
Nitrogen 3N233 99399933 Argon 3Ar3 for collision gas33br3
MASS ANALYZER
Mass Analyzer
Triple quadrupole6br6
Quadrupole
UF8Qarray888 II8br8
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
Microflow liquid chromatography22br22br 22
The Nexera Mikros uses flow rates from 1 to 500 22L2min and column I2D2 from 021 to 1 mm22br2
Sample Handling
The system can be used with a trap and elute system4 ideal for analyses with larger injection volumes or when some degree of sample cleanup is desirable44br4
Injection System
SIL040C XR autosampler00br00br 00
Injection volume range from 001 to 50 00L and uses a total injection method00br0
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Continuous 8full scan8 SIM8 MRM88br8
Data Analysis
MRM measurement is used to quantify Fab0derived peptides00br0
AUTOMATION AND SOFTWARE
Automation
Fully automated sample injection and analysis33br3
Software
LabSolutions LCMS3 LabSolutions CR3 LabSolutions MS33br3
OPERATIONAL FEATURES
Ease of Use
6p66b6Shimadzu Micro6ESI LCMS Source666b6 Designed for optimal sensitivity and ease of use666p6 6br 66
6p66b6Easy Adjustment666b6 X666Y adjustable stage 6 viewing camera for precise ESI spray needle positioning666p6 6br 66
6p66b6UF6Link Column Installation666b6 CTO6Mikros oven6s snap6in locking system ensures correct microflow column setup without disrupting needle position666p66br 66
Maintenance and Durability
The LCMS68060NX with the new ion guide UF6Qarray666 II and the UF6Lens666 II increases the robustness and minimizes downtime of the instrument66br6
Operating Conditions
1099C to 4099C 9ambient temperature99br9
Power and Cooling
100666240V6 50660 Hz6 Air cooling66br6
Dimensions and Footprint
510 mm 9W9 x 490 mm 9D9 x 510 mm 9H99br9
GENERAL INFORMATION
Brand and Model
Shimadzu Nexera Mikros LC1MS1MS1br1
Documentation and Support
Shimadzu Global Support4 Online manuals4 FAQs44br4
Compatibility and Connectivity
USB3 Ethernet3 LAN3 Wi3Fi3 MS data compatibility33br3
Configuration and Options
Dual ion source4 Various detector configurations44br4
Licensing and Certification
CE0 RoHS0 ISO 900100br0
Cost and Operational Expenses
Varies based on configuration9 operational cost depends on sample throughput and consumables used99br9
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