Shimadzu LCMS-8045

Mass Accuracy

±0.1 amu

Resolution

0.7 amu at m/z 200

Sensitivity

The LCMS-8045 offers the highest sensitivity in its class (as of August 2016) with IDLs of 2.03 fg (Reserpine, ESI+) and 2.09 fg (Chloramphenicol, ESI−). It ensures accurate, stable long-term data and detects pesticides at trace levels of 10 ppb.

Speed

World's fastest scan speed: 30,000 u/sec

Dynamic Range

> 10^7

Mass Range

10–1000 m/z

Detection Limit

See "Performance - Sensitivity" for IDLs of specific compounds.

Detector

Ultrafast Pulse-Counting Detector. Makes ultrafast sampling and polarity switching possible.

Ionization Method

Heated ESI

APCI is also available but requires a different needle.

Ion Source

Heated ESI probe which has high sensitivity and improves desolvation efficiency to facilitate the ionization of a wide range of compounds

Interface

ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization)

Gas Flow and Requirements

Drying Gas Flow: 10 L/min
Nebulizer Gas Flow: 3 L/min
Heating Gas Flow: 10 L/min

Mass Analyzer

Triple Quadrupole

Quadrupole

High-performance hyperbolic mass filter with a proven track record in LC/MS. Maintains high ion transmittance and high sensitivity, even at a high-speed scanning rate of 30,000 u/sec

Chromatography

Compatible with Shimadzu Nexera™ Series UHPLC and other high performance liquid chromatography (HPLC) systems.

Sample Handling

Can analyze complex biological fluids or food samples

Examples in the source include:

- Nitrofuran metabolites in fish
- Residual pesticides in herbal supplements
- Pharmaceuticals and personal care products (PPCPs) in water
- Amlodipine in plasma

SIL-40 autosampler available as part of the Nexera series, which can process the entire injection cycle time in as little as 7 seconds, allowing for continuous analysis and increased throughput

Injection System

SIL-40 autosampler available as part of the Nexera series with:
- Ultra-fast injection capabilities
- Ultra-low carryover

Data Acquisition

Ultra-high-speed due to the fast scan speed and polarity switching speed

Data Analysis

LabSolutions™ LCMS Software Suite:
- LabSolutions Connect™ – Simplifies LC-MS/MS workflows with automated MRM optimization and a tablet-like UI.
- LabSolutions Insight™ – Advanced data mining and analytics with review-by-exception, quality rules, and color-coded review.
- LabSolutions Insight Library Screening – MS/MS library search with MRM Spectrum Mode for accurate spectra from trace concentrations.
- Traverse MS™ – Multivariate analysis for fast MRM data processing, ideal for targeted metabolomics and pathway analysis.

Automation

Automatic tuning, data acquisition, and analysis

Software

See "Data Acquisition & Analysis - Data Analysis."

Ease of Use

Easy system maintenance reduces downtime. Features a newly designed ionization unit that can be easily attached and detached with a one-touch lever and without tools. Replacing the desolvation line (DL) and ESI capillary is quick and easy. The DL can be replaced without breaking vacuum

User-friendly software with an intuitive interface and pre-configured method packages

Maintenance and Durability

Easy maintenance procedures and robust ion source and sample introduction system contribute to durability. A test showed stable performance after 12,000 injections of plasma samples over 25 days

Operating Conditions

Temperature: 10–40°C, Humidity: 20-80% RH

Power and Cooling

Power: 100–240V AC, Cooling: Air-cooled

Dimensions and Footprint

0.6 m (W) x 0.8 m (D) x 1.5 m (H)

Brand and Model

Shimadzu LCMS-8045

Documentation and Support

The sources mention several brochures and application notes related to the LCMS-8045, including flyer codes for specific applications.

Compatibility and Connectivity

Compatible with Shimadzu Nexera™ Series UHPLC

Configuration and Options

The LCMS-8045 can be upgraded to the LCMS-8060

Various method packages and MRM libraries are available.

Licensing and Certification

For research use only. Not for use in diagnostic procedures.

Cost and Operational Expenses

Approx. $200,000 (initial) - operational expenses vary based on usage and maintenance