Thermofisher Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer

Mass Accuracy

<3 ppm RMS using external calibration, <1 ppm RMS using internal calibration

Resolution

7,500–500,000 (FWHM) at m/z 200
1M option: up to 1,000,000 (FWHM) at m/z 200

Sensitivity

• Injection: 2 μL of a 50 fg/μL reserpine solution (100 femtograms total)


• Flow Rate: 500 μL/min


• Minimum Signal-to-Noise (S/N) Ratio: 100:1


• Transition: m/z 609 → m/z 397 and m/z 448


• Mass Spectrometer Mode: Full scan, MS2 mode (m/z 165–615), unit resolution

Speed

OTMSn: Up to 40 Hz
ITMSn: Up to 45 Hz

Dynamic Range

>5000 within a single scan

Mass Range

Full MS Mass Range: 50 to 2000 m/z
MSn Mass Range: 40 to 2000 m/z

Detection Limit

Sub-picogram to femtogram range (specific to application)

Detector

Dual-dynode detector

Ionization Method

Not explicitly stated, but HESI probe is mentioned as a requirement in the sensitivity specifications.
OptaMax NG ion source has interchangeable HESI/APCI probes.

Ion Source

OptaMax NG ion source
Auto-Ready ion source
EASY-IC™ ion source

Interface

Electrospray Ionization (ESI)
Atmospheric Pressure Chemical Ionization (APCI)

Gas Flow and Requirements

Ultra-high purity helium (99.999%) with less than 1 ppm each of water, oxygen, and total hydrocarbons.
High purity nitrogen (99.5% pure, flow rate 15 L/min) gas supply for the API source and the ion routing multipole.

Mass Analyzer

Quadrupole
Linear ion trap
Orbitrap mass analyzer

Quadrupole

Quadrupole mass filter

Chromatography

Compatible with UHPLC
HPLC
Ion Chromatography

Sample Handling

Auto-sampler
96-well plate
Vial options

Injection System

Auto-sampler injection
Liquid chromatography compatible

Data Acquisition

Data dependent MS2 acquisition mode
Data dependent MS3 and higher order fragmentation methods
MSn, for n = 1 through

Data Analysis

Real-Time Library Search
Compound Discoverer™ software
Mass Frontier™ software
LipidSearch™ software

Automation

Fully automated system with auto-sampler integration

Software

Xcalibur™ software
Orbitrap IQ-X Tribrid MS instrument control software

Ease of Use

Fit-for-purpose software interface
Drag and drop user interface

Maintenance and Durability

Auto-Ready ion source simplifies maintenance
Stainless steel high-vacuum analyzer chamber

Operating Conditions

16–26 °C (59–78 °F)
Relative humidity must be 50–80% with no condensation

Power and Cooling

230 Vac ± 10% single phase
15 Amp
50/60 Hz
With earth ground
System averages 800 W (10,000 Btu/hr) output

Dimensions and Footprint

30 x 50 x 28 in. (77 x 127 x 70 cm)
1270 × 767 × 703 mm (50 × 30.2 × 27.7 in)

Brand and Model

Thermo Scientific™
Orbitrap™ IQ-X™ Tribrid™ mass spectrometer

Documentation and Support

Comprehensive user manuals
Software updates
Application support

Compatibility and Connectivity

USB
Ethernet
Wi-Fi
Remote operation support

Configuration and Options

UV Photodissociation
1M Resolution

Licensing and Certification

CE marked
ISO certified
Compliance with 21 CFR Part 11 (optional)

Cost and Operational Expenses

Varies based on configuration
Service contracts
Consumables