Flow Cytometer

Flow cytometers are powerful, precision-engineered instruments designed to analyze populations of cells and particles with unmatched accuracy through advanced laser-based fluorescence detection. In these systems, particles are suspended in a stream of fluid and guided in a single file through highly sensitive detectors, ensuring that each one is individually examined for its unique characteristics. Fluorescent markers, such as specifically conjugated antibodies, enable the detailed identification and quantification of cellular properties, leading to the widespread adoption of flow cytometers in basic and clinical research.read more

Essential Features

  • The flow cytometry equipment employs advanced technology with up to five lasers and 64 fluorescence detectors to enable high-dimensional cell sorting, offering flexible options from multiple tube sizes to index sorting into 96- or 384-well plates for deeper exploration of biological samples.
  • The system streamlines every stage of flow cytometry with full workflow automation, from sample processing and compensation to acquisition and analysis, ensuring consistent, reproducible results; enables seamless assay transfer for standardized, comparable data across instruments and sites; and meets regulatory requirements with 21 CFR Part 11-compliant software featuring user management, electronic signatures, automatic analysis reports, and time-stamped audit trails.
  • The high-performance, budget-friendly benchtop flow cytometer is designed for all user levels and laboratory types, offering enhanced sensitivity and resolution to detect up to 17 parameters.
  • Powered by advanced microchip technology, the cell sorter eliminates cell exposure to electrical charges, decompression, and conventional fluidics. Sorting takes place within a sterile, single-use, closed cartridge, ensuring maximum safety for both samples and operators.

Applications

  • Cell and gene therapy analytics: The flow cytometry instrument is ideal for scalable, standardized, and regulatory-compliant flow cytometry assays, making it particularly valuable for cell and gene therapy analytics while supporting a wide range of other research and manufacturing applications.
  • Nanoparticle and extracellular vesicle research: The nano flow cytometer machine is designed for high-sensitivity analysis of nanoparticles and extracellular vesicles as small as 40 nm, offering up to six fluorescent and five side scatter channels for comprehensive characterization, making it an essential tool for advancing nanoparticle and EV research. · Immunophenotyping: Flow cytometers are widely used to identify and classify immune cell populations based on surface and intracellular markers.
  • Cell cycle analysis: They help determine the distribution of cells across different phases of the cell cycle, aiding studies of proliferation and apoptosis.
  • Minimal residual disease (MRD) detection: Highly sensitive flow cytometry enables the detection of small populations of abnormal cells in hematological malignancies.
  • Stem cell research: They are employed to isolate and characterize stem cells by identifying specific surface markers.
  • Microbiology and infectious disease: Flow cytometers allow rapid detection, enumeration, and characterization of bacteria, viruses, and parasites.
  • Functional assays: Applications include measurement of cytokine production, enzyme activity, and cell signaling pathways.
  • Rare event detection: They provide high sensitivity for identifying circulating tumor cells, fetal cells, or other rare populations in blood.
  • Apoptosis and cell death studies: Flow cytometry enables the detection of apoptotic and necrotic cells using dyes and marker assays.
  • Drug discovery and screening: They are used in high-throughput screening to assess drug effects on cell viability, proliferation, and signaling.

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Frequesntly Asked Questions

How do I choose the right flow cytometer for my research needs?
To choose the right flow cytometer, start by assessing your research goals, sample types, and required parameters, such as the number of lasers, detection channels, sensitivity, and throughput. Then, consider features like ease of use, automation, data analysis capabilities, and scalability to ensure the instrument meets both your current and future experimental needs.
What applications are flow cytometers used for in life sciences?
In life sciences, flow cytometers are used for applications such as cell counting, immunophenotyping, cell cycle analysis, apoptosis detection, protein and biomarker quantification, microbial analysis, and functional assays. They also support specialized studies in areas like cancer research, immunology, stem cell biology, and extracellular vesicle characterization.
What are the differences between flow cytometers from various brands?
Flow cytometers from different brands vary in several key aspects, including the number and type of lasers, detection channels, and sensitivity; the range of supported applications (e.g., basic analysis vs. high-dimensional or spectral cytometry); throughput capacity; and compatibility with automation or high-throughput screening systems. They also differ in software usability, data analysis capabilities, maintenance requirements, service support, and cost, meaning the best choice depends on your research needs, budget, and preferred workflow.
Can I get a quote for a specific flow cytometer model?
Yes, most suppliers and manufacturers provide quotes for specific flow cytometer models upon request. You can typically obtain one by contacting their sales team directly through their website, providing details about the model, configuration, and any additional features or accessories you need.