APCI MS

Atmospheric Pressure Chemical Ionization (APCI) is a soft ionization technique used in mass spectrometry (MS) to analyze low-to-moderate polarity compounds. It operates under atmospheric pressure and is ideal for liquid chromatography-mass spectrometry (LC-MS) applications. In APCI, a heated nebulizer converts the liquid sample into an aerosol, and a corona discharge needle ionizes the analytes through gas-phase reactions. APCI is widely used for the detection of small molecules, including pharmaceuticals, lipids, and environmental pollutants. Compared to Electrospray Ionization (ESI), APCI is better suited for non-polar and thermally stable compounds, providing high sensitivity and reproducibility in quantitative analysis.read more