ICP-MS - Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis

• A sample introduction system
• An ion source
• A vacuum system
• A collision/reaction cell
• Ion optics
• A mass analyzer (commonly a quadrupole)
• A detector

Key Features of Inductively Coupled Plasma Mass Spectrometry

• ICP-MS is characterized by a working range spanning nine orders of magnitude, detection limits in the sub-parts-per-trillion (ppt) range, and the capability for isotopic analysis.
• The mass spectrometry system delivers high sensitivity and minimizes molecular interferences through optimized collision cell design and internal ion path geometry. It also includes advanced method development and diagnostic tools, a low-cost plasma system, and easily maintainable interfaces and sample injection components for efficient and reliable trace element analysis.
• The ICP-MS system combines high analytical performance with eco-friendly operation by reducing argon consumption and enabling high-throughput measurements with minimal manual intervention. It also features automated rinsing, spectral interference correction, aerosol dilution, signal stabilization, and preset methods for common analyses.
• The systems offer precise control over reaction chemistry, effectively resolving isobaric and polyatomic interferences for reliable multi-element analysis.
• The ICP-MS machine enables direct analysis of high-solids samples, reducing sample preparation and dilution time while efficiently removing polyatomic and doubly charged interferences for reliable results. Integrated software and hardware features streamline method setup, automate maintenance alerts, and simplify data review, enhancing overall laboratory efficiency and throughput.
• The ICP-MS instrument achieves 1500 Mcps/ppm with CeO formation below 2%, while consuming only half the argon compared to conventional instruments. It also offers 50% higher sample throughput, robust long-term stability across different matrices, and versatility for both research and routine analyses.
• The automation system fully integrates sample introduction, dilution, and valve management to streamline high-throughput analysis, reduce manual intervention, and minimize the risk of errors, while optimizing turnaround time and overall laboratory efficiency. A centralized ICP-MS analysis software provides comprehensive control of all components from a single interface, supports regulatory compliance, and promotes sustainability by reducing reagent consumption, power usage, and the need for disposable labware.

Applications of Inductively Coupled Plasma Mass Spectrometers

• Environmental analysis: ICP-MS is widely used in environmental monitoring due to its ability to detect trace metals at extremely low concentrations. It is commonly employed to analyze water, soil, and air samples for heavy metals such as lead, cadmium, and arsenic. These measurements help assess pollution levels, monitor industrial effluents, and ensure compliance with environmental regulations such as EPA 200.8.
• Food and agriculture: In the food and agricultural sector, ICP-MS applications in this field enable precise quantification of essential and toxic elements in crops, beverages, and processed foods. It is also used to detect contamination by heavy metals in imported or exported foods and to analyze nutritional content, including elements like iron, zinc, and selenium.
• Pharmaceutical and clinical analysis: ICP-MS is valuable in pharmaceutical research and clinical studies for trace element analysis in drugs, dietary supplements, and biological fluids. It is used to monitor impurities during pharmaceutical production and to perform isotopic analysis for medical research, including the tracking of radiotracers.
• Geochemistry and mining: Geochemists use ICP-MS to analyze rocks, soil, and mineral samples for exploration and resource evaluation. It allows accurate measurement of rare earth elements (REEs) and isotopic ratios, which can help track geochemical processes and support mineral resource assessment.
• Nuclear and isotope studies: ICP-MS plays a critical role in nuclear research by enabling precise isotope ratio determination, which is essential for radiometric dating. It is also used to detect trace radioactive isotopes in environmental or biological samples and in nuclear forensics for monitoring fuel or waste.
• Industrial and material science: ICP-MS is applied in industrial and materials research to ensure the quality and purity of metals, alloys, and electronic materials. It can detect trace contamination in semiconductors and assist in elemental mapping in advanced material studies.
• Forensic and toxicological analysis: Forensic scientists and toxicologists use ICP-MS to detect trace metals in human tissues, hair, and blood. It is instrumental in investigating poisoning cases, assessing environmental exposure, and analyzing metallic residues in crime scene investigations.

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