Agilent 6495D Triple Quadrupole LC/MS Liquid Chromatography Mass Spectrometry

Agilent 6495D Triple Quadrupole LC/MS

6495D Triple Quadrupole LC/MS offers high sensitivity, precise quantification, and robust performance for clinical and research labs.

STARTING PRICE

$300,000.00

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Features

High sensitivity for low-level detection
Enhanced accuracy for quantitative analysis
Streamlined user interface
Reliable and reproducible results
Advanced ion source design for optimal performance

Applications

Quantitative analysis in pharmacokinetics
Clinical diagnostics and biomarker discovery
Environmental analysis
Food safety testing
Pharmaceutical development and quality control

Product Specifications

PERFORMANCE

Mass Accuracy

< 1 ppm

Resolution

Unit = 0.7 Da
Wide = 1.2 Da
Widest = 2.5 Da
Narrow – 0.4 Da (m/z 5 to 1,500)

Sensitivity

ppq-level detection limits

Speed

700 MRM transitions/s
Scan Speed: 18,700 Da/s

Dynamic Range

> 10 orders of magnitude

MASS RANGE AND ANALYTE DETECTION

Mass Range

m/z 5-3000

Detection Limit

Low femtomolar range (fM)

Detector

Triple quadrupole with ESI (Electrospray Ionization)

IONIZATION, SOURCE AND INTERFACE

Ionization Method

ESI

Ion Source

ESI
AJS
APCI
MultiMode (ESI+APCI)
NanoESI

Interface

Electrospray Ionization (ESI), APCI (Atmospheric Pressure Chemical Ionization)

Gas Flow and Requirements

N2: 10-15 L/min
Sheath Gas: 11-15 psi

MASS ANALYZER

Mass Analyzer

Triple Quadrupole LC/MS

Quadrupole

3 quadrupoles (Q1, Q2, Q3)

CHROMATOGRAPHY AND SAMPLE HANDLING

Chromatography

Liquid Chromatography (LC)

Sample Handling

Automated sample introduction and sample prep options

Injection System

Agilent 1200 series auto-sampler

DATA ACQUISITION AND ANALYSIS

Data Acquisition

High-speed data acquisition up to 100 Hz

Data Analysis

MassHunter

AUTOMATION AND SOFTWARE

Automation

SWARM autotune

Software

MassHunter

OPERATIONAL FEATURES

Ease of Use

Built-in instrument intelligence designed for demanding, nonstop routine analysis.
Early maintenance feedback provides an easy-to-read dashboard to help visualize LC/MS instrument health and anticipate upcoming maintenance events.

Maintenance and Durability

VacShield enables quick and easy cleanup of matrix deposits without venting the system.

Operating Conditions

Temperature: 10-40°C
Humidity: 20-80% RH

Power and Cooling

110/220V AC
Cooling: Internal air cooling system

Dimensions and Footprint

91.5 cm x 77.3 cm x 47.5 cm

GENERAL INFORMATION

Brand and Model

Agilent 6495D Triple Quadrupole LC/MS

Documentation and Support

Agilent 6495 Triple Quadrupole LC/MS System: Intelligence that inspires confidence (brochure)
Application Note: Robustness of the 6495D Triple Quadrupole LC/MS System for nonstop pesticide analysis in black tea matrix
Elevate Your Phenotyping Workbench: Synergistic workflow overview (brochure)
Agilent Triple Quadrupole LC/MS Supplies: Quick reference guide
MassHunter Networked Workstation: Functional design specifications
MassHunter Workstation Requirements: System requirements guide

Compatibility and Connectivity

Seamless method transfer between Agilent LC/MS instruments on MassHunter 12 or higher.

Configuration and Options

Application-focused tuning and workflows facilitate analysis and quantitation of lipids, metabolites, peptides, proteins (digested), PFAS, and pesticides.

Licensing and Certification

ACT label from My Green Lab

Cost and Operational Expenses

High operational costs due to consumables and maintenance; Variable based on usage.