6560 Ion Mobility LC/Q-TOF LC/MS Instruments

Agilent 6560 Ion Mobility LC/Q-TOF

The Agilent 6560 Ion Mobility LC/Q-TOF combines ion mobility and LC-MS for high-resolution analysis.

STARTING PRICE

$800,000.00

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Features

High resolution and sensitivity
Integrated ion mobility spectrometry
Advanced software for data analysis
Seamless coupling with liquid chromatography for comprehensive analysis

Applications

Proteomics
Metabolomics
Complex sample analysis
Environmental testing
Pharmaceutical analysis

Product Specifications

PERFORMANCE

Mass Accuracy

Positive: <1 ppm RMS

Resolution

Ion Mobility Resolution (FWHM): >200
TOF Mass Resolution (FWHM): > 42,000 at m/z 2,722 independent of acquisition rate

Sensitivity

MS Sensitivity (positive): S/N (RMS) > 50:1. Measured with 1pg reserpine on column

Speed

MS Acquisition Rate: 50 spectra/second
MS/MS Acquisition Rate: 30 spectra/second
Up to 5 Hz acquisition rate can be used without compromising resolution for UHPLC compatibility

Dynamic Range

5 Orders

MASS RANGE AND ANALYTE DETECTION

Mass Range

TOF Mass Range: m/z 20-20,000

Detection Limit

Low femtomolar (fM) to picomolar (pM)

Detector

Quadrupole Time-of-Flight (Q-TOF)

IONIZATION, SOURCE AND INTERFACE

Ionization Method

Electrospray Ionization (ESI), APCI

Ion Source

Dual-AJS
Dual-ESI
APCI
MultiMode (ESI+APCI)
GC/APCI
NanoESI

Interface

Jet Stream ion source

Gas Flow and Requirements

Nitrogen (N2), 10–20 L/min

MASS ANALYZER

Mass Analyzer

Quadrupole Time of Flight LC/MS

Quadrupole

Quad Resolution (FWHM): 1.3 Da (autotune)
Quadrupole Isolation Mass Range: m/z 20-4000

CHROMATOGRAPHY AND SAMPLE HANDLING

Chromatography

The 6560C combines chromatography, ion mobility, and mass spectrometry
UHPLC

Sample Handling

Auto-sampler, direct injection

Injection System

Rheodyne Manual or Automated Injector

DATA ACQUISITION AND ANALYSIS

Data Acquisition

MassHunter

Data Analysis

MassHunter
MassHunter BioConfirm
MassHunter VistaFlux
Mass Profiler Professional
Classifier
Lipid Annotator
Agilent high resolution demultiplexing (HRdm 2.0) software

AUTOMATION AND SOFTWARE

Automation

An automated workflow for the analysis of protein phosphorylation

Software

MassHunter

OPERATIONAL FEATURES

Ease of Use

User-friendly interface with touch screen and software control

Maintenance and Durability

Ventless Maintenance: VacShield Technology
Utilizes Agilent VacShield for vent-free capillary removal

Operating Conditions

Temperature range: 10–40°C, Humidity: 20–80% RH

Power and Cooling

Power: 100–240 V, Cooling: Active or passive depending on configuration

Dimensions and Footprint

Approx. 55 x 55 x 30 cm (WxDxH)

GENERAL INFORMATION

Brand and Model

Agilent 6560C ion mobility Q-TOF LC/MS system
Agilent 6560 ion mobility LC/Q-TOF

Documentation and Support

Targeted Data Mining and Annotation of Untargeted High-Resolution Lipidomics Data application note.
Exact Structure Identification of Isomeric N-Glycans by High-Resolution Ion Mobility LC/Q-TOF application note.
Structural Analysis of the Multimers of Bovine Serum Albumin by Ion Mobility Mass Spectrometry application note.
Examining the Structural Influence of Site-Specific Phosphorylation by Ion Mobility Mass Spectrometry application note.
MassHunter Data Acquisition for LC/TOF and LC/Q-TOF Familiarization Guide.
MassHunter Workstation 11.0 for LC/TOF and LC/Q-TOF Installation Guide.
MassHunter Networked Workstation Functional Design Specifications.

Compatibility and Connectivity

Agilent partners with innovators who provide technologies and software that expand the core capabilities of the LC/Q-TOF portfolio.

Configuration and Options

Learn more about additional capabilities and visit the compatibility matrix to see which ones are offered for your LC/Q-TOF.

Licensing and Certification

CE, RoHS, FDA 21 CFR Part 11 compliance

Cost and Operational Expenses

Varies by region, high initial cost, consumables and maintenance cost considerations.