Agilent NEW ExD Cell for LC/Q-TOF
The Agilent NEW ExD Cell for LC/Q-TOF enhances ion transmission and sensitivity for precise analysis.
Features
- Enhanced ion transmission and resolution
- Optimized for LC/Q-TOF systems
- Increased sensitivity for complex analyses
- Superior performance with complex sample matrices
Applications
- Drug discovery
- Proteomics and biomarker discovery
- Environmental analysis
- Food safety and quality testing
- Clinical research and diagnostics
Product Specifications
PERFORMANCE
Mass Accuracy
± 0.5 amu
Resolution
>40,000 FWHM (Full Width at Half Maximum)
Sensitivity
Low pg/μL
Speed
Up to 10,000 Da/sec
Dynamic Range
>5 orders of magnitude
MASS RANGE AND ANALYTE DETECTION
Mass Range
Synergy with the inherent advantages of the 6545XT such as ultrahigh vacuum and quadrupole isolation up to 4,000 m/z makes the system well-suited for top- and middle-down characterization of larger proteins.
Detection Limit
10-100 fg/μL
Detector
ESI (Electrospray Ionization) + APPI (Atmospheric Pressure Photoionization)
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Electrospray Ionization (ESI)
APCI
APPI
APCI
APPI
Ion Source
Dual Ion Source (ESI + APCI)
Interface
Jet Stream™ Technology
Gas Flow and Requirements
50-100 psi nitrogen or argon
MASS ANALYZER
Mass Analyzer
Quadrupole Time of Flight LC/MS
Quadrupole
The Agilent ExD cell is an add-on for the Agilent 6545XT AdvanceBio LC/Q-TOF
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
LC/Q-TOF
Sample Handling
Automated sample introduction, 96-well plate compatible
Injection System
Manual or automated syringe pump
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Real-time data acquisition with full scan and selected ion monitoring (SIM)
Data Analysis
Rich ECD spectra can be quickly, intuitively, and confidently interpreted using Agilent BioConfirm 12.1 for bottom-up peptide mapping or the freeware tool ExDViewer for top-down analyses.
AUTOMATION AND SOFTWARE
Automation
Fully automated workflows with remote control and monitoring
Software
MassHunter Acquisition 11.0 Update 2 for LC/TOF and LC/Q-TOF
ExDControl 3.6
ExDControl 3.6
OPERATIONAL FEATURES
Ease of Use
Exceptionally high efficiency ECD means less time spent fine-tuning to maximize performance, and greater applicability for difficult and lower-abundance peptides and proteins.
Maintenance and Durability
Filament Life: >500 hours
Operating Conditions
Temperature: 15-40°C
Humidity: 30-80% RH
Humidity: 30-80% RH
Power and Cooling
Power: 100-240 V
Cooling: Air-cooled, external liquid cooling required
Cooling: Air-cooled, external liquid cooling required
Dimensions and Footprint
60 x 60 x 30 cm (L x W x H)
GENERAL INFORMATION
Brand and Model
Agilent ExD cell and Agilent 6545XT AdvanceBio LC/Q-TOF
Documentation and Support
ExDViewer 4.6
ExD Cell Site Preparation Checklist
ExD Cell Site Preparation Checklist
Compatibility and Connectivity
Supported Instruments: 6545XT LC/Q-TOF
Configuration and Options
The ExD cell is field-installable and can be flexibly installed after-the-fact to maximize your existing investment in a 6545XT LC/Q-TOF.
Licensing and Certification
CE
RoHS
FDA-compliant (for medical applications)
RoHS
FDA-compliant (for medical applications)
Cost and Operational Expenses
Cost: $100,000-$200,000
Maintenance: Moderate annual cost depending on usage
Maintenance: Moderate annual cost depending on usage
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