Shimadzu Nexera Mikros Triple Quadrupole LC-MS/MS
Shimadzu Nexera Mikros: Compact LC-MS/MS system for ultra-sensitive microflow analysis with excellent detection limits.
Features
- High sensitivity with microflow analysis
- Robust and stable performance
- Easy, familiar operation
- Versatile system supporting various flow rates
Applications
- Pharmaceutical research applications
- Food research applications
- Environmental research applications
- Clinical research applications
- Toxicology
- Biomarker discovery
- Environmental monitoring
Product Specifications
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PERFORMANCE
Mass Accuracy
33031 Da 3depending on calibration33br3
Resolution
8gt8 087 Da 8depending on MS mode88br8
Sensitivity
High Bioanalytical Sensitivity
Speed
7p77b7Minimized System Volume 7 Gradient Delay777b7 Achieved with the SIL740C XR autosampler777s programmable loop cut7off777p7 7br 77
7p77b7Efficient Sample Handling777b7 A high7pressure valve diverts the sample loop once the needle is drained777p7 7br 77
7p77b7Key Benefit777b7 Reduces microflow analysis run times777p7
Dynamic Range
0900763 999 6295 99g9mL for the analysis of trastuzumab9derived peptides99br9
MASS RANGE AND ANALYTE DETECTION
Mass Range
10 to 25000 m5z5br5
Detection Limit
6p66b6Lower Limit of Detection 6LOD6666b6 06025 66g6mL for signature peptides from the Fab region of antibodies666p6 6br 66
6p66b6Enhanced Sensitivity666b6 Shim6pack MC PLONAS 267 66m columns achieve lower LODs and LOQs666p6
Detector
Triple quadrupole mass spectrometer0br0
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Electrospray ionization 6ESI66br6
Ion Source
5p55b5Shimadzu Micro5ESI555 LCMS Source555b5 Optimized for precision and sensitivity555p5 5br 55
5p5Available Options555p5 5br 55
5ul5 5br 55
5li55b5Micro5ESI 8060555b5 Compatible with LCMS5804558050580605NX5 systems555li5 5br 55
5li55b5Micro5ESI555b5 Standard option for versatile applications555li5 5br 55
55ul55br 55
Interface
Micro4ESI4br4
Gas Flow and Requirements
Nitrogen 7N277 99799977 Argon 7Ar7 for collision gas77br7
MASS ANALYZER
Mass Analyzer
Triple quadrupole6br6
Quadrupole
UF3Qarray333 II3br3
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
Microflow liquid chromatography22br22br 22
The Nexera Mikros uses flow rates from 1 to 500 22L2min and column I2D2 from 021 to 1 mm22br2
Sample Handling
The system can be used with a trap and elute system7 ideal for analyses with larger injection volumes or when some degree of sample cleanup is desirable77br7
Injection System
SIL440C XR autosampler44br44br 44
Injection volume range from 041 to 50 44L and uses a total injection method44br4
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Continuous 0full scan0 SIM0 MRM00br0
Data Analysis
MRM measurement is used to quantify Fab2derived peptides22br2
AUTOMATION AND SOFTWARE
Automation
Fully automated sample injection and analysis00br0
Software
LabSolutions LCMS9 LabSolutions CR9 LabSolutions MS99br9
OPERATIONAL FEATURES
Ease of Use
6p66b6Shimadzu Micro6ESI LCMS Source666b6 Designed for optimal sensitivity and ease of use666p6 6br 66
6p66b6Easy Adjustment666b6 X666Y adjustable stage 6 viewing camera for precise ESI spray needle positioning666p6 6br 66
6p66b6UF6Link Column Installation666b6 CTO6Mikros oven6s snap6in locking system ensures correct microflow column setup without disrupting needle position666p66br 66
Maintenance and Durability
The LCMS38060NX with the new ion guide UF3Qarray333 II and the UF3Lens333 II increases the robustness and minimizes downtime of the instrument33br3
Operating Conditions
1099C to 4099C 9ambient temperature99br9
Power and Cooling
100999240V9 50960 Hz9 Air cooling99br9
Dimensions and Footprint
510 mm 0W0 x 490 mm 0D0 x 510 mm 0H00br0
GENERAL INFORMATION
Brand and Model
Shimadzu Nexera Mikros LC6MS6MS6br6
Documentation and Support
Shimadzu Global Support3 Online manuals3 FAQs33br3
Compatibility and Connectivity
USB2 Ethernet2 LAN2 Wi2Fi2 MS data compatibility22br2
Configuration and Options
Dual ion source4 Various detector configurations44br4
Licensing and Certification
CE5 RoHS5 ISO 900155br5
Cost and Operational Expenses
Varies based on configuration8 operational cost depends on sample throughput and consumables used88br8
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