Orbitrap Exploris 480 Mass Spectrometer Mass Spectrometer

Thermofisher Orbitrap Exploris 480 Mass Spectrometer

Orbitrap Exploris 480: High-resolution mass spectrometer for biopharma, proteomics, and isotope ratio analysis.

STARTING PRICE

$975,000.00

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Features

Market-leading resolution & mass accuracy
Compact footprint
Isotope ratio analysis with high-resolution accuracy
Maximum data certainty and robustness
High throughput for large-scale studies

Applications

Proteomics
Biopharma
Isotope ratio analysis
Large-scale studies
Translational science research

Thermofisher Orbitrap Exploris 480 Mass Spectrometer

Product Specifications

PERFORMANCE

Mass Accuracy

<3 ppm RMS with external calibration over 24 hr. and without any kind of mass recalibration, <1 ppm RMS drift for at least 5 days

Resolution

Up to 480,000 at m/z 2001

Sensitivity

MS/MS: 50 fg Reserpine on Column S/N 100:1
SIM: 50 fg Reserpine on Column S/N 150:1

Speed

Up to 40 Hz at resolution setting of 7500 at m/z 2002
Scan rate: Up to 40 Hz at resolution setting at 7,500

Dynamic Range

>5000:1 within one spectrum
>5,000 within a single Orbitrap mass analyzer spectrum

MASS RANGE AND ANALYTE DETECTION

Mass Range

40 to 8000 m/z
Standard mass range m/z 40–6,000
Up to m/z 8,000 with BioPharma option

Detection Limit

Full Scan: < 1.5 fg reserpine on column

tMS2: < 1.5 fg reserpine on column

tSIM: < 0.8 fg reserpine on column

Detector

Independent Charge Detector

IONIZATION, SOURCE AND INTERFACE

Ionization Method

Soft electrospray ionization (ESI)
Heated electrospray ionization (H-ESI)

Ion Source

Thermo Scientific™ OptaMax™ NG ion source
EASY-IC™ ion source

Interface

Atmospheric pressure ionization (API) interface

Gas Flow and Requirements

Source gas: high-purity nitrogen (>99% pure at 600 ± 50 kPa [6.0 ± 0.5 bar, 87 ± 7 psi])

HCD collision gas: ultra-high-purity nitrogen (UHP > 99.999% pure) at 600 ± 50 kPa [6.0 ± 0.5 bar]

For EASY IC option: ultra-high-purity nitrogen (UHP > 99.999% pure) at 600 ± 50 kPa [6.0 ± 0.5 bar]

MASS ANALYZER

Mass Analyzer

Orbitrap
Ultra-high-field Thermo Scientific Orbitrap mass analyzer with 4 kV central electrode voltage
Thermo Scientific™ Orbitrap™ mass analyzer

Quadrupole

Advanced quadrupole technology (AQT)
Segmented quadrupole mass filter for precursor ion selection with variable precursor isolation width from 0.4 to 2,000 Da

CHROMATOGRAPHY AND SAMPLE HANDLING

Chromatography

LC-MS

Sample Handling

Automatic sample introduction, capable of handling liquid samples via direct infusion or LC systems

Injection System

Compatible with autosamplers or manual injection, with flow rates up to 1 mL/min

DATA ACQUISITION AND ANALYSIS

Data Acquisition

High-performance PC with Intel® processor

High-resolution LED monitor

Windows® Enterprise OS (LTSC)

Real-time data acquisition & control

Auto calibration of ion transfer & analysis

Data Analysis

Thermo Scientific™ Orbitrap Exploris™ instrument control software
Thermo Scientific™ Xcalibur™ software

AUTOMATION AND SOFTWARE

Automation

AcquireX data acquisition workflows provide comprehensive small molecule sample profiling on an LC timescale using automated, logic-based sample re-injection with inter-run inclusion and exclusion lists

Software

Thermo Scientific™ Orbitrap Exploris™ software

Thermo Scientific™ Xcalibur™ software

Thermo Scientific™ Proteome Discoverer™ software

Thermo Scientific™ BioPharma Finder™ software

Thermo Scientific™ ProSightPD™ software

Thermo Scientific™ Compound Discoverer™ software

Thermo Scientific™ TraceFinder™ software

Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)

OPERATIONAL FEATURES

Ease of Use

Next-generation software with intuitive tuning, single-click calibration, drag-and-drop method setup, and pre-defined experiments

Maintenance and Durability

Prolonged robustness and improved serviceability increase uptime

Operating Conditions

Operating temperature: 18–27 °C (64–81 °F)

Relative humidity: 20–80% (no condensation)

Indoor use up to 3,000 m (10,000 ft) altitude

Power and Cooling

2×208–240 Vac single phase, 15 A, 50/60 Hz for instrument and source vacuum pump

115 or 230 Vac single phase, 15 A, 50/60 Hz for auxiliary forepump

208–240 Vac single phase, 15 A, 50/60 Hz for data system

System power output: 3440 W (11,730 Btu/h) for air conditioning needs

Dimensions and Footprint

534 × 763 × 703 mm (21 × 30 × 27.7 in)
120 kg (265 lb) without data system, vacuum rough pumps, and optional items

GENERAL INFORMATION

Brand and Model

Thermo Scientific™, Orbitrap Exploris™ 480 Mass Spectrometer
Orbitrap Exploris 480 MS

Documentation and Support

Comprehensive user manuals, application notes, and 24/7 technical support through Thermo Fisher service network

Compatibility and Connectivity

Compatible with Thermo Scientific chromatography systems (e.g., Dionex) and third-party systems via USB, Ethernet, and Wi-Fi

Configuration and Options

Thermo Scientific™ BioPharma option

Thermo Scientific™ EASY-Spray™ NG ion source

Thermo Scientific™ NanoSpray Flex™ NG ion source

APCI probe for OptaMax NG ion source

Thermo Scientific™ FAIMS Pro™ Duo interface

Licensing and Certification

For Research Use Only. Not for use in diagnostic procedures

Cost and Operational Expenses

Initial cost: $200,000 - $400,000 USD
Operational expenses include consumables (e.g., columns, reagents), maintenance, and service contracts (~$20,000 per year)