Waters BioAccord LC-MS System
Advanced LC-MS system for automated biopharmaceutical analysis with high precision.
Features
- Automated biopharmaceutical analysis
- High precision
- Integrated LC-MS
- Reliable performance
Applications
- Biopharmaceuticals
- Proteomics
- Metabolomics
- Drug discovery
Product Specifications
PERFORMANCE
Mass Accuracy
Intact Mass Analysis: <20 ppm (top 3 Glycoform peaks), <5 ppm (mass precision)
Peptide Mapping: <10 ppm (precursor mass accuracy)
Released Glycan Analysis: 5 ppm mass filter
Peptide Mapping: <10 ppm (precursor mass accuracy)
Released Glycan Analysis: 5 ppm mass filter
Resolution
High resolution (oa-Tof mass analyzer)
Sensitivity
Peptide Mapping: >3 orders of intensity (identified peptides)
Released Glycan Analysis: >0.5% of the total (relative abundance for identification)
Released Glycan Analysis: >0.5% of the total (relative abundance for identification)
Speed
Up to 80 Hz (optical detectors)
Dynamic Range
3 orders of intensity (identified peptides in peptide mapping)
MASS RANGE AND ANALYTE DETECTION
Mass Range
Approximately 350 to 7,000 Da (identified peptides in peptide mapping)
Detection Limit
Identification of expected glycan components with relative abundance >0.5% of the total
Detector
ACQUITY RDa™ Detector (mass detector)
ACQUITY Premier TUV Detector
ACQUITY Premier FLR Detector
ACQUITY Premier eLambda Detector (optical)
ACQUITY Premier TUV Detector
ACQUITY Premier FLR Detector
ACQUITY Premier eLambda Detector (optical)
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Electrospray Ionization (ESI)
Ion Source
Integrated adjustment-free plug-and-play probe
Interface
Adjustment-free high-performance ZSpray™ dual-orthogonal atmospheric pressure ionization electrospray interface
Gas Flow and Requirements
Not specified
MASS ANALYZER
Mass Analyzer
High resolution, high stability oa-Tof mass analyzer
Quadrupole
Not specified
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
ACQUITY™ Premier UPLC™ with MaxPeak™ High Performance Surfaces (HPS) Technology
Sample Handling
Microtiter plates: 96 and 384
Vial plates: 48 position 2.00 mL
Micro-centrifuge tube plates: 48 position 0.65 mL, 24 position 1.50 mL
Sample compartment temperature: 4.0 to 40 °C (settable in 0.1 °C increments)
Vial plates: 48 position 2.00 mL
Micro-centrifuge tube plates: 48 position 0.65 mL, 24 position 1.50 mL
Sample compartment temperature: 4.0 to 40 °C (settable in 0.1 °C increments)
Injection System
Standard: 0.1 to 10.0 µL
With optional extension loop: Up to 1000 µL
With optional extension loop: Up to 1000 µL
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Full scan (MS)
Full scan with fragmentation (data-independent acquisition)
Full scan with fragmentation (data-independent acquisition)
Data Analysis
Supported workflows: Intact mass analysis, peptide mapping, peptide MAM, released glycan analysis
Optional three reference libraries for released glycan analysis
Optional three reference libraries for released glycan analysis
AUTOMATION AND SOFTWARE
Automation
Fully automated and differentially pumped vacuum system
Automated instrument setup and calibration
Run-to-run performance monitoring
Automatic issue resolution or step-by-step guidance
Self-calibrating, self-optimizing, self-sufficient tool
Simple, consistent, and automated setup
Automated instrument setup and calibration
Run-to-run performance monitoring
Automatic issue resolution or step-by-step guidance
Self-calibrating, self-optimizing, self-sufficient tool
Simple, consistent, and automated setup
Software
waters_connect™ informatics software
waters_connect™ with UNIFI™ Scientific Information System
waters_connect™ with UNIFI™ Scientific Information System
OPERATIONAL FEATURES
Ease of Use
Fully integrated solution that simplifies high-performance LC-MS analysis
Easy-to-use system solution
Automated setup and calibration for users of all experience levels
Easy-to-use system solution
Automated setup and calibration for users of all experience levels
Maintenance and Durability
Adjustment-free ZSpray™ interface
Integrated adjustment-free probe
Optimized for unparalleled robustness and reproducibility
Run-to-run performance monitoring
Integrated adjustment-free probe
Optimized for unparalleled robustness and reproducibility
Run-to-run performance monitoring
Operating Conditions
Solvent pH range: 2 to 10
Column compartment temperature: 20.0 to 90.0 °C (settable in 0.1 °C increments)
Column compartment temperature: 20.0 to 90.0 °C (settable in 0.1 °C increments)
Power and Cooling
Air-cooled split-flow turbo pump
Dimensions and Footprint
Not specified
GENERAL INFORMATION
Brand and Model
Brand: Waters Corporation
Model: BioAccord™ System
Mass Detector: ACQUITY RDa™ Detector
Liquid Chromatograph: ACQUITY Premier UPLC™
Column Management: ACQUITY Premier Column Heater (CH-A), ACQUITY Premier Column Manager (CM-A)
Optical Detectors: ACQUITY Premier TUV Detector, ACQUITY Premier FLR Detector, ACQUITY Premier eLambda Detector
Model: BioAccord™ System
Mass Detector: ACQUITY RDa™ Detector
Liquid Chromatograph: ACQUITY Premier UPLC™
Column Management: ACQUITY Premier Column Heater (CH-A), ACQUITY Premier Column Manager (CM-A)
Optical Detectors: ACQUITY Premier TUV Detector, ACQUITY Premier FLR Detector, ACQUITY Premier eLambda Detector
Documentation and Support
Step-by-step guidance in software
Site Preparation Guide and Product Release Notes
Contact local sales representative for detailed specifications
Site Preparation Guide and Product Release Notes
Contact local sales representative for detailed specifications
Compatibility and Connectivity
Supported by waters_connect™ informatics software and UNIFI™ Scientific Information System
Configuration and Options
Solvent Management: Binary (up to four solvents) or Quaternary (blend up to four solvents)
Optical Detectors: TUV (190-700 nm), FLR (Excitation 200-890 nm, Emission 210-900 nm), PDA eλ (190-800 nm)
Column Management: Single column (max 150 mm) or two columns (max 150 mm)
Sample Capacity: Various microtiter and vial/tube plate options
Injection Volume: Up to 1000 µL with extension loop
Optional: Three reference libraries for released glycan analyses
Optical Detectors: TUV (190-700 nm), FLR (Excitation 200-890 nm, Emission 210-900 nm), PDA eλ (190-800 nm)
Column Management: Single column (max 150 mm) or two columns (max 150 mm)
Sample Capacity: Various microtiter and vial/tube plate options
Injection Volume: Up to 1000 µL with extension loop
Optional: Three reference libraries for released glycan analyses
Licensing and Certification
CE, CB, NRTL (CAN/US), RCM
Cost and Operational Expenses
Not specified
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