Waters Mass Spectrometry Imaging (MSI)
Imaging mass spectrometry solution for detailed spatial molecular characterization.
Features
- High-resolution imaging
- Spatial molecular analysis
- Advanced characterization
- Accurate data collection
Applications
- Histopathology
- Material science
- Biomedical imaging
- Clinical diagnostics
Product Specifications
PERFORMANCE
Mass Accuracy
Not specified
Resolution
High-resolution MS; enhanced selectivity with ion mobility separation and SONAR (SYNAPT XS HDMS)
Sensitivity
Waters Full Spectrum Molecular Imaging enables comprehensive visualization of molecular distributions, mapping various molecule types including small molecules, drugs, metabolites, lipids, and peptides.
Speed
Designed to deliver information with minimal time and effort
Dynamic Range
Not specified
MASS RANGE AND ANALYTE DETECTION
Mass Range
Not specified
Detection Limit
Not specified
Detector
Not specified
IONIZATION, SOURCE AND INTERFACE
Ionization Method
DESI (Desorption Electrospray Ionization)
MALDI (Matrix-Assisted Laser Desorption Ionization)
MALDI (Matrix-Assisted Laser Desorption Ionization)
Ion Source
DESI source
MALDI source
MALDI source
Interface
Not specified
Gas Flow and Requirements
Uses gas phase separation of ions via ion mobility (specific gas flow requirements not provided).
MASS ANALYZER
Mass Analyzer
High-resolution MS; integrates ion mobility separation with MALDI and DESI imaging; SYNAPT XS features SONAR for enhanced selectivity
Quadrupole
While not explicitly mentioned, quadrupole technology is often integrated within MS systems.
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
No chromatographic separation; MS imaging enables direct spatial molecular distribution analysis
Sample Handling
DESI: No sample preparation required
MALDI: Requires matrix application; thin sections (10 µM–15 µM) prepared via cryostat
DESI allows for non-destructive analysis, enabling multiple imaging experiments on the same sample
MALDI: Requires matrix application; thin sections (10 µM–15 µM) prepared via cryostat
DESI allows for non-destructive analysis, enabling multiple imaging experiments on the same sample
Injection System
Not applicable (direct surface analysis, no injection required)
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Uses HDI software for co-registration, acquisition, and processing of spatially resolved molecular data.
Data Analysis
HDI software processes and visualizes imaging data, allowing for optical image overlay and molecular-morphological data integration.
AUTOMATION AND SOFTWARE
Automation
Intuitive, fully integrated workflow designed to simplify complex analyses
Software
HDI imaging software (comprehensive MS imaging workflow support, leveraging mass spectral and ion mobility data).
OPERATIONAL FEATURES
Ease of Use
User-friendly, intuitive interface with an integrated workflow
Maintenance and Durability
Robust and reliable; single-vendor system-level support ensures compatibility and maximized productivity
Operating Conditions
Operates under vacuum conditions for gas phase separation of ions.
Power and Cooling
Not specified
Dimensions and Footprint
Not specified
GENERAL INFORMATION
Brand and Model
Brand: Waters
Models: SYNAPT XS, DESI XS, SYNAPT HDMS, SELECT SERIES MRT (for MALDI support)
System: Waters Full Spectrum Molecular Imaging
Models: SYNAPT XS, DESI XS, SYNAPT HDMS, SELECT SERIES MRT (for MALDI support)
System: Waters Full Spectrum Molecular Imaging
Documentation and Support
Single-vendor system-level support available; documentation provided on the Waters website
Compatibility and Connectivity
Ensured through the single-vendor system
Configuration and Options
Choice of complementary ionization techniques (DESI and MALDI)
Variable spatial resolutions available for DESI
Variable spatial resolutions available for DESI
Licensing and Certification
"For Clinical Research Use Only. Not for use in diagnostic procedures."
MALDI SYNAPT XS classified as a Class 1 Laser Product
Ethical approval details included for human sample studies
MALDI SYNAPT XS classified as a Class 1 Laser Product
Ethical approval details included for human sample studies
Cost and Operational Expenses
Not specified
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