Waters SYNAPT XS
High-resolution mass spectrometry system with advanced ion mobility capabilities.
Features
- Advanced ion mobility
- High resolution
- Complex sample analysis
- Enhanced separation
Applications
- Complex sample analysis
- Biomedical research
- Proteomics
- Structural elucidation
Product Specifications
PERFORMANCE
Mass Accuracy
Not specified
Resolution
Enhanced Resolution mode (W): 80,308
High Resolution mode (W): 70,365
Resolution mode (V): 59,216. Delivers UPLC-compatible mass resolution.
High Resolution mode (W): 70,365
Resolution mode (V): 59,216. Delivers UPLC-compatible mass resolution.
Sensitivity
Enhanced sensitivity due to redesigned StepWave™ XS.
Superior sensitivity compared to SYNAPT G2-Si for selected small molecules.
FastDDA/HD-DDA generates fragmentation data with low limits of detection.
TAP fragmentation provides superior sensitivity.
Superior sensitivity compared to SYNAPT G2-Si for selected small molecules.
FastDDA/HD-DDA generates fragmentation data with low limits of detection.
TAP fragmentation provides superior sensitivity.
Speed
FastDDA/HD-DDA allows generation of fragmentation data with enhanced speed.
Designed for expedient discovery.
Designed for expedient discovery.
Dynamic Range
SONAR experiments exhibit 3–4 orders linear dynamic range.
Plasma protein analysis shows 3–4 orders linear dynamic range.
Extended Flight Tube delivers matrix-tolerant dynamic range.
Plasma protein analysis shows 3–4 orders linear dynamic range.
Extended Flight Tube delivers matrix-tolerant dynamic range.
MASS RANGE AND ANALYTE DETECTION
Mass Range
Not specified
Detection Limit
Low limits of detection for FastDDA/HD-DDA, specific values not provided.
Detector
Ion Detection System, Dual Stage Reflectron, Ion Mirror.
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Supports MALDI, DESI™ XS, ionKey™, ESI, ESCi™, APCI, APGC, NanoFlow™ ESI, REIMS, and ASAP.
Ion Source
LOCKMASS SPRAY, ANALYTE SPRAY.
Interface
Information not found in the sources. Supports a variety of chromatographic inlets.
Gas Flow and Requirements
Not specified
MASS ANALYZER
Mass Analyzer
Time-of-Flight (Tof) Mass Spectrometer.
Includes a Quadrupole.
Features an Extended Flight Tube.
Equipped with a Dual Stage Reflectron and Ion Mirror.
Utilizes TriWave™ IMS.
Includes a Quadrupole.
Features an Extended Flight Tube.
Equipped with a Dual Stage Reflectron and Ion Mirror.
Utilizes TriWave™ IMS.
Quadrupole
Includes a quadrupole.
StepWave XS features redesigned segmented quadrupole transfer optics.
In SONAR, the quadrupole separates co-eluting precursor masses by scanning the mass range.
StepWave XS features redesigned segmented quadrupole transfer optics.
In SONAR, the quadrupole separates co-eluting precursor masses by scanning the mass range.
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
Supports a variety of chromatographic inlets, UPLC-compatible mass resolution.
Sample Handling
Not specified
Injection System
Not specified
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Features SONAR™/MSE/HDMSE as DIA modes.
Offers FastDDA/HD-DDA.
Employs IMS-based DIA modes.
Utilizes TAP fragmentation.
Offers FastDDA/HD-DDA.
Employs IMS-based DIA modes.
Utilizes TAP fragmentation.
Data Analysis
Delivers multi-layered, information-rich data.
HDI™ Software simplifies mass spectral imaging.
Dedicated software for mining and compiling data.
SONAR data enhances fragmentation spectral clarity.
HDI™ Software simplifies mass spectral imaging.
Dedicated software for mining and compiling data.
SONAR data enhances fragmentation spectral clarity.
AUTOMATION AND SOFTWARE
Automation
IntelliStart™ Embedded routines for automated system checks.
Enables automated HDX (higher order structure determination).
Enables automated HDX (higher order structure determination).
Software
HDI™ Software, Dedicated software for data mining and compilation.
Waters supplies application-focused software.
Waters supplies application-focused software.
OPERATIONAL FEATURES
Ease of Use
Engineered Simplicity™: high performance, system versatility, and ease of operation.
Maintenance and Durability
Inherent reproducibility and repeatability.
StepWave XS enhances robustness.
Waters Global Services offers support to maintain peak performance.
StepWave XS enhances robustness.
Waters Global Services offers support to maintain peak performance.
Operating Conditions
Not specified
Power and Cooling
Information not found in the sources. Diagram shows air-cooled turbomolecular pumps.
Dimensions and Footprint
Not specified
GENERAL INFORMATION
Brand and Model
SYNAPT™ XS Ion Mobility Time-of-Flight Mass Spectrometer. Waters Corporation.
Documentation and Support
Waters Global Services for world-renowned support.
Quality support and consultative services.
ACE Award for technical knowledge, issue resolution, and process support.
Quality support and consultative services.
ACE Award for technical knowledge, issue resolution, and process support.
Compatibility and Connectivity
UPLC-compatible mass resolution.
Configuration and Options
Offers a variety of inlet options.
Licensing and Certification
Not specified
Cost and Operational Expenses
Information not found in the sources, but Waters Service and Support offerings address budget realities.
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