Waters Atmospheric Pressure Gas Chromatography (APGC) Source

APGC source enables high-sensitivity gas chromatography-mass spectrometry at atmospheric pressure.

STARTING PRICE

$100,000.00

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Features

  • Enables APGC-MS
  • High selectivity
  • Enhanced sensitivity
  • Compatible with multiple systems
  • Efficient workflow

Applications

  • Gas chromatography-MS
  • Volatile compound analysis
  • Environmental testing
  • Pharmaceutical research
  • Food safety analysis
Atmospheric Pressure Gas Chromatography (APGC) Source

Product Specifications

PERFORMANCE

Mass Accuracy
Not Specified
Resolution
Not Specified
Sensitivity
The APGC system provides a highly-sensitive analytical solution, with enhanced sensitivity due to soft ionization and StepWave ion optics, which allow for greater sampling and removal of background species.
Speed
Not Specified
Dynamic Range
Not Specified

MASS RANGE AND ANALYTE DETECTION

Mass Range
Not Specified
Detection Limit
Detection demonstrated at femtogram (fg) level (e.g., 5fg for chlorpyriphos-methyl, 50fg for endosulfan-alpha).
Detector
The Xevo TQ-S is a tandem quadrupole mass spectrometer, which serves as the mass detector.

IONIZATION, SOURCE AND INTERFACE

Ionization Method
The ionization method is APGC, which is similar to APCI. It includes soft ionization, charge transfer, and protonation mechanisms.
Ion Source
The ion source is based on the Waters ESCi (Electrospray/APCI) source with a specific ion chamber for APGC, including a corona pin creating a nitrogen plasma.
Interface
The APGC is an atmospheric pressure ionization source coupled with a GC, with the GC eluent flow meeting nitrogen make-up gas at the transfer line tip.
Gas Flow and Requirements
Make-up flow: nitrogen at 80-90 psi
Auxiliary flow: nitrogen at 50-100 L/h (200-300 L/h with peek tubing)
Cone gas flow: nitrogen at 170-225 L/h (minimum 150 L/h)

MASS ANALYZER

Mass Analyzer
The mass analyzer is the Xevo TQ-S.
Quadrupole
The Xevo TQ-S is a tandem quadrupole mass spectrometer, indicated by "TQ-S" and use of MRM transitions.

CHROMATOGRAPHY AND SAMPLE HANDLING

Chromatography
APGC is used with gas chromatography, allowing higher column flows for better separation, as it is not a vacuum source.
Sample Handling
The system aims to reduce sample volume to minimize matrix effects and contamination. It analyzes pesticide residues in various matrices (e.g., spinach, pear).
Injection System
Not Specified

DATA ACQUISITION AND ANALYSIS

Data Acquisition
Data acquisition involves selecting MRM transitions, optimizing collision energy, and using MassLynx® autodwell for peak analysis.
Data Analysis
Calibration curves for dichlorvos and azinphos-methyl show good linearity (R² = 0.997), with repeatability evaluations showing good results.

AUTOMATION AND SOFTWARE

Automation
Not Specified
Software
MassLynx® software is used for data acquisition and analysis.

OPERATIONAL FEATURES

Ease of Use
The Xevo TQ-S with APGC is described as a sensitive, easy-to-use analytical system, with a quick changeover between LC and GC.
Maintenance and Durability
The system's robustness was tested over five days, showing good repeatability. High voltage read-back can indicate contamination of the corona pin.
Operating Conditions
APGC operates at atmospheric pressure
GC oven >250 °C
Make-up flow at 80-90 psi
Auxiliary flow: 50-100 L/h
Cone gas: 170-225 L/h
Power and Cooling
Not Specified
Dimensions and Footprint
Not Specified

GENERAL INFORMATION

Brand and Model
Waters Xevo® TQ-S with APGC ionization.
Documentation and Support
Documentation includes a manual for corona current optimization and installation details. Waters Corporation provides contact information.
Compatibility and Connectivity
The APGC source is compatible with Waters Universal Sources. Nitrogen make-up, auxiliary, and cone gas flows are supplied by the GC and MS.
Configuration and Options
The system can select between proton transfer and charge transfer ionization or operate in mixed mode.
Licensing and Certification
Not Specified
Cost and Operational Expenses
Not Specified

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