Shimadzu LCMS-8045
Shimadzu LCMS-8045: Ultra-fast, high-sensitivity LC-MS with heated ESI probe for diverse analytical applications.
Features
- Highest sensitivity in its class
- Fastest scan and polarity switching speeds
- Easy maintenance with quick part replacements
- Robust performance for long-term use
Applications
- Food safety
- Environmental analysis
- Pharmaceutical testing
- Toxicology
- Other quantitative analyses
Product Specifications
PERFORMANCE
Mass Accuracy
±0.1 amu
Resolution
0.7 amu at m/z 200
Sensitivity
The LCMS-8045 offers the highest sensitivity in its class (as of August 2016) with IDLs of 2.03 fg (Reserpine, ESI+) and 2.09 fg (Chloramphenicol, ESI−). It ensures accurate, stable long-term data and detects pesticides at trace levels of 10 ppb.
Speed
World's fastest scan speed: 30,000 u/sec
Dynamic Range
> 10^7
MASS RANGE AND ANALYTE DETECTION
Mass Range
10–1000 m/z
Detection Limit
See "Performance - Sensitivity" for IDLs of specific compounds.
Detector
Ultrafast Pulse-Counting Detector. Makes ultrafast sampling and polarity switching possible.
IONIZATION, SOURCE AND INTERFACE
Ionization Method
Heated ESI
APCI is also available but requires a different needle.
APCI is also available but requires a different needle.
Ion Source
Heated ESI probe which has high sensitivity and improves desolvation efficiency to facilitate the ionization of a wide range of compounds
Interface
ESI (Electrospray Ionization), APCI (Atmospheric Pressure Chemical Ionization)
Gas Flow and Requirements
Drying Gas Flow: 10 L/min
Nebulizer Gas Flow: 3 L/min
Heating Gas Flow: 10 L/min
Nebulizer Gas Flow: 3 L/min
Heating Gas Flow: 10 L/min
MASS ANALYZER
Mass Analyzer
Triple Quadrupole
Quadrupole
High-performance hyperbolic mass filter with a proven track record in LC/MS. Maintains high ion transmittance and high sensitivity, even at a high-speed scanning rate of 30,000 u/sec
CHROMATOGRAPHY AND SAMPLE HANDLING
Chromatography
Compatible with Shimadzu Nexera™ Series UHPLC and other high performance liquid chromatography (HPLC) systems.
Sample Handling
Can analyze complex biological fluids or food samples
Examples in the source include:
- Nitrofuran metabolites in fish
- Residual pesticides in herbal supplements
- Pharmaceuticals and personal care products (PPCPs) in water
- Amlodipine in plasma
SIL-40 autosampler available as part of the Nexera series, which can process the entire injection cycle time in as little as 7 seconds, allowing for continuous analysis and increased throughput
Examples in the source include:
- Nitrofuran metabolites in fish
- Residual pesticides in herbal supplements
- Pharmaceuticals and personal care products (PPCPs) in water
- Amlodipine in plasma
SIL-40 autosampler available as part of the Nexera series, which can process the entire injection cycle time in as little as 7 seconds, allowing for continuous analysis and increased throughput
Injection System
SIL-40 autosampler available as part of the Nexera series with:
- Ultra-fast injection capabilities
- Ultra-low carryover
- Ultra-fast injection capabilities
- Ultra-low carryover
DATA ACQUISITION AND ANALYSIS
Data Acquisition
Ultra-high-speed due to the fast scan speed and polarity switching speed
Data Analysis
LabSolutions™ LCMS Software Suite:
- LabSolutions Connect™ – Simplifies LC-MS/MS workflows with automated MRM optimization and a tablet-like UI.
- LabSolutions Insight™ – Advanced data mining and analytics with review-by-exception, quality rules, and color-coded review.
- LabSolutions Insight Library Screening – MS/MS library search with MRM Spectrum Mode for accurate spectra from trace concentrations.
- Traverse MS™ – Multivariate analysis for fast MRM data processing, ideal for targeted metabolomics and pathway analysis.
- LabSolutions Connect™ – Simplifies LC-MS/MS workflows with automated MRM optimization and a tablet-like UI.
- LabSolutions Insight™ – Advanced data mining and analytics with review-by-exception, quality rules, and color-coded review.
- LabSolutions Insight Library Screening – MS/MS library search with MRM Spectrum Mode for accurate spectra from trace concentrations.
- Traverse MS™ – Multivariate analysis for fast MRM data processing, ideal for targeted metabolomics and pathway analysis.
AUTOMATION AND SOFTWARE
Automation
Automatic tuning, data acquisition, and analysis
Software
See "Data Acquisition & Analysis - Data Analysis."
OPERATIONAL FEATURES
Ease of Use
Easy system maintenance reduces downtime. Features a newly designed ionization unit that can be easily attached and detached with a one-touch lever and without tools. Replacing the desolvation line (DL) and ESI capillary is quick and easy. The DL can be replaced without breaking vacuum
User-friendly software with an intuitive interface and pre-configured method packages
User-friendly software with an intuitive interface and pre-configured method packages
Maintenance and Durability
Easy maintenance procedures and robust ion source and sample introduction system contribute to durability. A test showed stable performance after 12,000 injections of plasma samples over 25 days
Operating Conditions
Temperature: 10–40°C, Humidity: 20-80% RH
Power and Cooling
Power: 100–240V AC, Cooling: Air-cooled
Dimensions and Footprint
0.6 m (W) x 0.8 m (D) x 1.5 m (H)
GENERAL INFORMATION
Brand and Model
Shimadzu LCMS-8045
Documentation and Support
The sources mention several brochures and application notes related to the LCMS-8045, including flyer codes for specific applications.
Compatibility and Connectivity
Compatible with Shimadzu Nexera™ Series UHPLC
Configuration and Options
The LCMS-8045 can be upgraded to the LCMS-8060
Various method packages and MRM libraries are available.
Various method packages and MRM libraries are available.
Licensing and Certification
For research use only. Not for use in diagnostic procedures.
Cost and Operational Expenses
Approx. $200,000 (initial) - operational expenses vary based on usage and maintenance
Compare similar items
-
Shimadzu LCMS-8050
The Shimadzu LCMS-8050 is designed for high-sensitivity and high-speed analysis in liquid chromatography and mass spectrometry, suitable for both qual...
-
PerkinElmer QSight® 220 Multi-Opt Dual Source System
The PerkinElmer QSight® 220 Multi-Opt Dual Source System offers innovative dual-source technology, ensuring reliable and high-performance chemical an...
-
PerkinElmer QSight 420 Multi-Opt Dual Source System
The QSight 420 Multi-Opt Dual Source System by PerkinElmer is designed for laboratories demanding high-performance mass spectrometry with exceptional ...